Objektorientiert-modellbasierte Charakterisierung, Überwachung und Regelung des technisch unterstützen Herz-Kreislauf-Systems

• Object-oriented model-based characterization, monitoring and control of the technically assisted cardiovascular system

Gesenhues, Jonas Franz-Hermann; Abel, Dirk (Thesis advisor); Hein, Marc (Thesis advisor)

Aachen (2019)
Dissertation / PhD Thesis

Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2019

Abstract

This thesis focusses on methods that allow direct use of object-oriented modelling within model-based control concepts. Object-oriented modelling has so far been used primarily in simulation. However, the benefits of object-oriented modeling can also simplify and speed up the design process of model-based control methods. The cardiovascular system, which is technically supported by a blood pump, is considered as the focus of application of these methods. Considering current trends of increasing digitization and networking in medicine, various approaches are conceived within the work, which expand the treatment options of technical heart support, as well as make them safer and more efficient. To implement the methods in practice, a research platform consisting of various software and hardware components was developed within this thesis. The research platform constitutes an animal experimental based prototype of a highly digitized and networked surgical or intensive care treatment environment and allows for the simple online application of higher control strategies. In addition, a comprehensive experimental database was set up for the automated evaluation of large amounts of data. In various clinically relevant application examples, the methods are examined in simulation as well as in vivo. The applications cover various aspects of characterization, monitoring and control of the technically supported cardiovascular system. In addition, the thesis also includes the design and initial evaluation of a conceptually new heart assist device.

Institutions

• Chair and Institute of Automatic Control [416610]